Inflammation is a complex immune response involving innate immune cells, adaptive immune cells, and a variety of mediators characterized by pleiotropic activity.
Different cell types can secrete same cytokines or a single cytokine can act on several different cell types, and similar functions can be stimulated by different cytokines.
Traditional approach blocking a single pathway or a small number of target molecules could not adequately address the complexity involved in the immune-mediated inflammation.
Induction of Immune-regulatory circuit could be a better choice as it concurrently handles multiple pro-inflammatory pathways.
Multilateral, simultaneous control of inflammatory cells and cytokines at the site of action is the most efficient approach to controlling inflammatory diseases.
Shaperon’s multi-functional compounds, TGR5 agonist, demonstrate excellent control of inflammation by down-regulating multiple pro-inflammatory cytokines by epigenetic reprogramming.
In addition, Shaperon’s TGR5 agonist concurrently increases the number of immune-regulatory cells, critical to pro-inflammatory pathways.
Shaperon’s NuGel® down-regulates TSLP which is crucial
pro-inflammatory cytokine in pathogenesis of AD.
Infiltrating inflammatory cells (Th17 cells, mast cell, eosinophil,
and neutrophil) and inflammatory cytokines are down-regulated while the production of IFN-gamma is up-regulated.
NuGel® also shows significant improvement in clinical symptoms of atopic dermatitis by normalizing TH1/TH2 balance.
Skin remodeling is promoted through up-regulation of various fiber proteins.
A plethora of pathogenic signaling pathways are simultaneously activated in septic patients.
Shaperon’s strategy of targeting intrinsic immune regulatory mechanisms shows a drastic effect in inhibiting broad spectrum of pathways that are activated in sepsis.
NuSepin® increases the number of immune-regulatory MDSCs and anti-inflammatory signatures of MDSCs by epigenetic reprogramming that are crucial in resolving systemic inflammation during sepsis.
Misfolded and aggregated amyloid β bind to pattern recognition receptors on microglia, astrocytes and infiltrating macrophages, and trigger inflammatory response.
Neuro-inflammatory mediators contribute to neuronal apoptosis and impair cognition and memory eventually.
Shaperon’s NuCerin® reduces loads of Aβ plaques in the frontal cortex of Alzheimer mice and brain inflammation by regulating the activation of microglia and reactive astrocytes.
Thus, neuro-inflammatory modulator NuCerin® prevents loss of neurons and memory thereby.
Ulcerative colitis is caused by abnormal activation of immune system in the gut.
Shaperon’s NuColin® significantly decreases immune cells (T cells, B cells, and myeloid cells) recruitment in the bowel via TGR5 pathway.
NuColin® markedly decreases expression of pro-inflammatory cytokines such as IL-6, IL-1β, TNF-α in DSS-induced mice colitis model